PGI2 Is a Novel SGI1-Relative Multidrug-Resistant Genomic Island Characterized in Proteus mirabilis

Abstract

A novel 61,578-bp genomic island named <i>Proteus</i> genomic island 2 (PGI2) was characterized in <i>Proteus mirabilis</i> of swine origin in China. The 23.85-kb backbone of PGI2 is related to those of <i>Salmonella</i> genomic island 1 and <i>Acinetobacter</i> genomic island 1. The multidrug resistance (MDR) region of PGI2 is a complex class 1 integron containing 14 different resistance genes. PGI2 was conjugally mobilized in <i>trans</i> to <i>Escherichia coli</i> in the presence of a conjugative IncC helper plasmid.