Highly Stereoselective Synthesis of 1,3‐Dienes through an Aryl to Vinyl 1,4‐Palladium Migration/Heck Sequence

Abstract

An efficient aryl to vinyl 1,4-palladium migration/Heck sequence was developed for the stereoselective synthesis of 1,3-dienes. High stereoselectivity was observed not only for 1,3-dienes bearing two similar aryl groups at terminal positions, but also for those with configurations shown to be unfavorable with previous methods.