Cell Death and Disease · 2018 · 70 citations · 35 references
Life SciencesCell BiologyMolecular BiologyApoptosisGene ExpressionTranscriptomicsDegenerative Spine DiseaseIntervertebral Disc DiseaseNeurodegenerative DiseasesCircular Rna RegulationErbb Receptor SignalingIntervertebral Disc DegenerationIntervertebral Disc PathologyIntervertebral DiscsLumbar Degenerative Disc DiseaseNucleus Pulposus DegenerationTherapeutic Target Identification
Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
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NCBI GEO: archive for functional genomics data sets—update
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Circular RNAs are a large class of animal RNAs with regulatory potency
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