Multiple genetically modified <scp>GTKO</scp>/<scp>hCD</scp>46/<scp>HLA</scp>‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood - Concepedia

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Multiple genetically modified <scp>GTKO</scp>/<scp>hCD</scp>46/<scp>HLA</scp>‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood

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Citations

25

References

2018

Year

Jan‐Michael Abicht, Riccardo Sfriso, Bruno Reichart, Matthias Längin, Katja Gahle, Gisella Puga Yung, Jörg D. Seebach, Robert Rieben, David Ayares, Eckhard Wolf,

Xenotransplantation

Abstract

GTKO, hCD46, and HLA-E expression in porcine hearts reduced complement deposition, complement dependent injury, and myocardial NK cell infiltration during perfusion with human blood. This tested combination of genetic modifications may minimize damage from acute human-anti-pig rejection reactions and improve myocardial function after xenotransplantation.

References

	Year	Citations

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