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PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53

Mutant Tp53MedicineParp-1 InhibitionOncogenic AgentPhotocarcinogenesisCell DeathCancer BiologyCancer CellsTumor SuppressorRadiation OncologyOncologyCell BiologyCancer ResearchOxidative Stress