Different qualifiers of AUS/FLUS thyroid FNA have distinct <i>BRAF</i>, <i>RAS</i>, <i>RET</i>/<i>PTC</i>, and <i>PAX8</i>/<i>PPARg</i> alterations

Abstract

BRAF and RAS mutations are associated with different AUS/FLUS qualifiers and hence have different risks of malignancy. Consequently, a hybrid molecular and morphological subcategorization system could improve the malignancy risk stratification of thyroid FNA samples diagnosed as AUS/FLUS. Cancer Cytopathol 2018;126:317-25. © 2018 American Cancer Society.