Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2

Abstract

Taken together, our findings suggest that low levels of acetaldehyde are cardioprotective whereas high levels are damaging in an ex vivo model of I/R injury and that ALDH2 is a major, but not the only, regulator of cardiac acetaldehyde levels and protection from I/R.