Metallated porphyrin-doped Conjugated Polymer Nanoparticles for Efficient Photodynamic Therapy of Brain and Colorectal Tumor Cells

Abstract

CPNs were well incorporated into glioblastoma and macrophage cells with localization in lysosomes. SW480 cells were less efficient incorporating CPNs with localization in the plasma membrane. In all cell lines PDT treatment was efficient inducing oxidative stress that triggered apoptosis.