Electrochemical oxidation pathway of the anti-cancer agent dasatinib using disposable pencil graphite electrode and its adsorptive stripping voltammetric determination in biological samples

Abstract

The present study describes the use of pencil graphite electrode (PGE) for the investigation of electro-oxidation mechanism and voltammetric stripping determination of dasatinib (DST) in Britton-Robinson buffer solution (BR). Relating to cyclic voltammetric studies, an irreversible oxidation signal was obtained at about 1.0 V. The oxidation electrode process is adsorption-controlled and pH-dependent. For quantitative determination of DST, square wave adsorptive stripping voltammetry (AdsSWV) was employed in BR of pH 3.0. The oxidation peak current varies linearly with the DST concentration in the range of 0.0092 – 1.0 µM. Dedection (LOD) and quantification (LOQ) values are founded as 0.0028 µM and 0.0092 µM, respectively. The developed AdsSWV method based on disposible and cheap PGE was applied successfuly to the real urine samples and the recovery results are given in the range of 97.94% to 100.82%.