Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-<i>tert</i>-butyl Janadolide and Its Biological Evaluation

Abstract

To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide-peptide hybrid, a macrolactonization strategy was explored. We prepared des-<i>tert</i>-butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the <i>tert</i>-butyl group is necessary for the desired bioactivity.