Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

Abstract

Terretonin N (<b>1</b>), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of <i>Nocardiopsis</i> sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of <b>1</b> were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of <i>Nocardiopsis</i> sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound <b>1</b> were studied using different microorganisms and a cervix carcinoma cell line, respectively.