Metal-free NaI/TBHP-mediated sulfonylation of thiols with sulfonyl hydrazides

Abstract

A highly efficient sulfonylation of thiols has been achieved through the metal-free NaI/TBHP-mediated cross-coupling of sulfonyl hydrazides and thiols at room temperature. This method provides a convenient and practical route to thiosulfonates in 84-99% yields (39 examples) with wide functional group compatibility.