Concepedia

Mechanistic insights into transferable polymyxin resistance among gut bacteria

Yongchang Xu, Jingxia Lin, Tao Cui, Swaminath Srinivas, Youjun Feng

Journal of Biological Chemistry · 2018 · 75 citations · 64 references

DOIFull text

Open access

Concepts

Abstract

Our results provide mechanistic insights into transferable MCR-1 polymyxin resistance, raising the prospect of rational design of small molecules that reverse bacterial polymyxin resistance, as a last-resort clinical option to combat pathogens with carbapenem resistance.

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