Palladium-catalyzed site-selective arylation of aliphatic ketones enabled by a transient ligand

Abstract

Transition metal-catalyzed direct C-H bond functionalization enabled by transient ligands has become an attractive topic. Here we report a palladium-catalyzed site-selective arylation of β-C(sp³)-H bonds in aliphatic ketones with β-alanine as the transient ligand.