Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)₂ as the oxidant

Abstract

The chromanone scaffold is considered as a privileged structure in drug discovery. Herein, we report a highly efficient PhI(OAc)₂ mediated regioselective, direct C-H hydroxylation of chromanones. This method offers easy access to substituted 6-hydroxy chromanones in moderate to good isolated yields, thus paving the way for their pharmaceutical studies.