Evaluation of the oxidative stress–related genes <i>ALOX5, ALOX5AP, GPX1, GPX3</i> and <i>MPO</i> for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population

Abstract

Our study presents novel evidence for main effects of MPO gene on type 2 diabetes mellitus susceptibility. Furthermore, our study supported the association between variants of oxidative stress-related genes ( GPX1 and MPO) and carotid plaques in type 2 diabetes mellitus patients, which indicated a modulation of type 2 diabetes mellitus-related vascular complication susceptibility by genetic predisposition.