Visible-Light-Induced External Radical-Triggered Annulation To Access CF₂-Containing Benzoxepine Derivatives

Abstract

A facile and diversified synthesis of functionalized CF₂-containing benzoxepine derivatives via photoredox catalysis was achieved in this work. This novel protocol features broad substrate scope, mild reaction conditions, operational simplicity, easy scale-up, and versatile derivatization, which would facilitate its practical and broad applications in the construction of valuable and synthetically challenging heterocycles.