Publication | Closed Access
<i>In situ</i> formation of large pore silica–MnO<sub>2</sub> nanocomposites with H<sup>+</sup>/H<sub>2</sub>O<sub>2</sub> sensitivity for O<sub>2</sub>-elevated photodynamic therapy and potential MR imaging
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Citations
21
References
2018
Year
A cancer cell-specific, endogenous H<sup>+</sup>/H<sub>2</sub>O<sub>2</sub>-activated, and O<sub>2</sub> self-sufficient nanocomposite is engineered and characterized. Such NPs, with good biocompatibility and rapid response to intracellular H<sup>+</sup>/H<sub>2</sub>O<sub>2</sub>, have demonstrated improved therapeutic effects in targeted cancer cells and activated MR signals in vitro, providing a promising strategy for effective PDT against tumor hypoxia.
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