Publication | Closed Access
Enantioselective Di-/Perfluoroalkylation of β-Ketoesters Enabled by Cooperative Photoredox/Nickel Catalysis
77
Citations
50
References
2018
Year
Efficient and enantioselective radical difluoroalkylation and perfluoroalkylation reactions of β-ketoesters were successfully developed through an asymmetric photoredox and nickel catalysis cascade. This protocol provides R<sub>f</sub>-containing quaternary stereocenters in up to 67% yield and 95:5 er with ethyl iododifluoroacetate and perfluoroalkyl iodides (C<sub>3</sub>F<sub>7</sub>I and C<sub>4</sub>F<sub>9</sub>I) as radical sources under extremely mild conditions.
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