IncX3 Epidemic Plasmid Carrying <i>bla</i> _NDM-5 in Escherichia coli from Swine in Multiple Geographic Areas in China

Abstract

Six imported pigs originating from Guangdong, Henan, and Hunan provinces in China during October 2015 to February 2017 were cultured and found to be positive for meropenem-resistant <i>Escherichia coli</i> The samples yielded 9 <i>E. coli</i> isolates of diverse sequence types carrying <i>bla</i>_NDM-5 on IncX3 (8 isolates from 5 farms) or IncFII (1 isolate from 1 farm) plasmids. The <i>mcr-1</i> gene was coharbored by 4 isolates. The IncX3 plasmids (∼46 kb) carrying <i>bla</i>_NDM-5 were identical or nearly identical to each other.