Publication | Closed Access
A quantitative LC-MS/MS method for simultaneous determination of deuvortioxetine, vortioxetine and their carboxylic acid metabolite in rat plasma, and its application to a toxicokinetic study
21
Citations
14
References
2018
Year
Metabolomic ProfilingToxicokinetic StudyRat PlasmaStable MethodPharmacological StudyToxicologyAnalytical ChemistryLiquid ChromatographyChromatographyBiochemistryMetabolomicsExperimental ToxicologyPharmacologyQuantitative Lc-ms/ms MethodCarboxylic Acid MetaboliteForensic ToxicologyMass SpectrometryMedicinePharmacokinetics
A rapid, simple, efficient and stable method based on LC-MS/MS for simultaneous determination of deuvortioxetine, vortioxetine and their carboxylic acid metabolite in rat plasma has been established and validated.
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