Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients - Concepedia

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Publication | Open Access

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

DOI Full Paper Access

96

Citations

29

References

2018

Year

Jean‐Marc Hoffmann, Maria‐Luisa Schubert, Lei Wang, Angela Hückelhoven, Leopold Sellner, Sophia Stock, Anita Schmitt, Christian Kleist, Ulrike Gern, Angelica Loskog,

Frontiers in Immunology

Abstract

Untreated CLL patients might constitute a challenge for long-lasting CART effects <i>in vivo</i> since only a low number of T<sub>N</sub> among the CART product could be generated. Depletion of malignant B cells before starting CART production might be considered to increase the T<sub>N</sub>/T<sub>E</sub> ratio within the CART product.

References

	Year	Citations

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