Phenolic composition, antioxidant and antinociceptive activities of <i>Syringa vulgaris</i> L. bark and leaf extracts

Abstract

Metabolite profile, antioxidant and antinociceptive activities of <i>Syringa vulgaris</i> bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by <i>in vitro</i> DPPH^● and ABTS^●+ assays and by <i>in vivo</i> hot-plate method in mice, respectively. Our results could lay the scientific basic of future clinical perspectives of lilac bark and leaf.