Manganese/cobalt-catalyzed oxidative C(sp³)–H/C(sp³)–H coupling: a route to α-tertiary β-arylethylamines

Abstract

Reported herein is an oxidative coupling reaction of an α-C(sp³)-H bond of amine with a benzylic C(sp³)-H bond through Mn or Co catalysis to provide diverse collections of α-tertiary β-arylethylamines. This protocol features an easily installed and removable coordinating activation group, a wide scope of substrates, low-cost metal catalysts, easily available starting materials and synthetic simplicity.