Guidelines for experimental models of myocardial ischemia and infarction

TLDR

Myocardial infarction, driven by ischemia with or without reperfusion, remains a major cardiovascular event, and reperfusion itself can cause injury, underscoring the need for rigorous basic and translational research. The consensus statement aims to provide best‑practice recommendations for animal models of myocardial ischemia and infarction. The authors develop consensus recommendations for designing and performing animal models of myocardial ischemia and infarction. A podcast version of the guidelines is available at ajpheart.podbean.com/e/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction.

Abstract

Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction. With increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results, the goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models. Listen to this article’s corresponding podcast at ajpheart.podbean.com/e/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction/.