Donepezil Reverses Dendritic Spine Morphology Adaptations and <i>Fmr1</i> Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure

Abstract

These findings indicate that AIE produces long-lasting decreases in dendritic spine density and changes in Fmr1 gene expression in the hippocampal formation, suggesting morphological and epigenetic mechanisms underlying previously reported behavioral deficits after AIE. The reversal of these effects by subchronic, post-AIE donepezil treatment indicates that these AIE effects can be reversed by up-regulating cholinergic function.