Pharmacokinetic bioequivalence, safety and acceptability of Ornibel^®, a new polymer composition contraceptive vaginal ring (etonogestrel/ethinylestradiol 11.00/3.474 mg) compared with Nuvaring^® (etonogestrel/ethinylestradiol 11.7/2.7 mg)

Abstract

Ornibel^® is bioequivalent to Nuvaring^® in terms of efficacy, safety, tolerability and acceptability. The new polymer composition provides Ornibel^® with more stability and gradual hormonal release during the first day of use, particularly for ethinylestradiol.