Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (PPAR-γ), the fat mass and obesity-associated (FTO), and the melanocortin-4 receptor (MC4R) genes

Abstract

1. MetS-related abnormalities can be genetically determined, however only some of these relationships can be demonstrated due to the categorical division of symptoms according to the IDF criteria from 2009. 2. The A/A genotype of the <i>FTO</i> rs9939609 polymorphism increases the risk of hyperglycemia, and the C/C genotype of the <i>PPAR-γ</i> rs1801282 variant entails elevated blood pressure in 45-60-year-old women.