Spectral, Thermal and Antimicrobial Properties of Novel Mixed Ligand-Metal Complexes Derived from Saccharinate Complexes and Azo Dye Ligand

Abstract

Background and Objective: Saccharin and saccharinate (sac) complexes and its anion have critical importance with biological, biochemical and pharmacological properties. The main objective of this study was to synthesize the novel mixed ligand complexes from the complexes [M(Sac) 2 (H 2 O) 4 ]2H 2 O [M: Mn(II), Co(II), Ni(II), Cu(II) and Cd(II)] with a second neutral ligand [L:(mmppa): 5-Methyl-4-(4methylphenylazo)-2H-pyrazole-3-ylamine]. Methodology: The structures of the complexes were characterized by elemental analysis, magnetic susceptibility, FT-IR, mass and electronic spectral studies and thermal analysis. Antimicrobial (antibacterial and anticandidal) activities of the complexes were tested against Enterococcus faecalis ATCC 51299, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 and Candida albicans ATCC 64548.