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A Study on Acute Toxicities of Essential Oils Used in Endodontic Treatment
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1984
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ToxicologyAcute ToxicityClinical ToxicologyChromatographyAllergyOmega-3 Fatty AcidClove OilEssential OilsExperimental ToxicologyPharmacologyToxic SymptomsForensic ToxicologyHerb-drug InteractionEndodontic TreatmentEnvironmental ToxicologyMedicinePharmacokineticsAcute ToxicitiesDrug Analysis
Acute toxicities of three essential oils, clove oil, eucalyputus oil, peppermint oil (mentha oil, JP), and methyl salicylate which is main constituent of winter green oil, were studied with use of male mice of ddY strain weighing 18.0∿22.0g. Each drug was diluted in olive oil to be administered orally in the dose of 0.1ml/10g to the mice which had not been fed for 20 hours prior to the test. Toxic symptoms and changes in the body weight gain of the surviving mice were observed and the number of death was recorded for 7 days. LD_<50> with 95% confidence limits was calculated with use of Litchfield-Wilcoxon's method. Results were as follows : 1. LD_<50> was 1820 (1490∿2220) mg/kg for clove oil, 3320 (2770∿3980) mg/kg for eucalyputus oil, 2410 (2170∿2680) mg/kg for peppermint oil, 1390 (1250∿1540) mg/kg for methyl salicylate. 2. The ratio of toxic potency to clove oil was 0.55 for eucalyputus oil, 0.76 for peppermint oil, 1.3 for methyl salicylate. 3. There was significant difference (p<0.05) in the acute toxicity between clove oil and eucalyputus oil, peppermint oil or methyl salicylate. 4. Restraint of growth was observed in each surviving mouse administered one of the drugs. 5. The toxic symptoms in the mice administered methyl salicylate or peppermint oil were more serious than those in the mice administered clove oil or eucalyputus oil.