Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor - Concepedia

Concepedia

Publication | Open Access

Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor

DOI Full Paper Access

35

Citations

32

References

2017

Year

Vasiliki Liakouli, Jacobo Elíes, Yasser M. El‐Sherbiny, Margherita Scarcia, Gary Grant, Giuseppina Abignano, Emma Derrett‐Smith, Filomena Esteves, Paola Cipriani, Paul Emery,

Annals of the Rheumatic Diseases

Abstract

Our data reveal a new pathway by which TGF-β suppresses angiogenesis in SSc, through decreased fibroblast Cav-1 expression and subsequent PEDF secretion. This pathway may present a promising target for new therapeutic interventions in SSc.

References

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