(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster

Abstract

We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy-to-handle KF(¹⁸ F). The reactions exhibited high functional-group tolerance and needed only an ambient atmosphere. This ¹⁸ F addition to C-C unsaturated bonds proceeded with extraordinarily high radiochemical yields.