<scp>FAM</scp>20C could be targeted by <scp>TET</scp>1 to promote odontoblastic differentiation potential of human dental pulp cells

Abstract

TET1 knockdown suppressed odontoblastic differentiation by restraining its direct binding to FAM20C promoter, and hence inhibiting FAM20C hydroxymethylation and subsequent transcription. These results suggest that TET1 potentially promotes the cytodifferentiation potential of hDPCs through its DNA demethylation machinery and upregulation of FAM20C protein expression.