MiR-144 Increases Intestinal Permeability in IBS-D Rats by Targeting OCLN and ZO1

Abstract

Up-regulation of miR-144 could promote intestinal hyperpermeability and impair the protective effect of the epithelial barrier by directly targeting OCLN and ZO1. miR-144 is likely a key regulator of intestinal hyperpermeability and could be a potential therapeutic target for IBS-D.