Palladium-catalyzed enantioselective C(sp²)–H arylation of ferrocenyl ketones enabled by a chiral transient directing group

Abstract

Palladium-catalyzed enantioselective C(sp²)-H activation of ferrocenyl ketones is achieved through utilizing catalytic, inexpensive l-tert-leucine as a chiral transient directing group. The transformation allows rapid access to ferrocene scaffolds simultaneously possessing planar- and stereogenic central chirality, widely applied in the ferrocene-based chiral ligand families.