Concepedia

Destabilization of DNA G-Quadruplexes by Chemical Environment Changes during Tumor Progression Facilitates Transcription

Hisae Tateishi‐Karimata, Keiko Kawauchi, Naoki Sugimoto

Journal of the American Chemical Society · 2017 · 101 citations · 46 references

DOIFull text

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Concepts

Abstract

ions attenuate the transcription of certain oncogenes by stabilizing G-quadruplex structures. Our findings provide insight into the novel mechanism of overexpression of certain G-rich genes during tumor progression.

References

46

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J Huppert, Shankar Balasubramanian · Nucleic Acids Research · 2005 · 1.7K citations · Full text

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Inhibition of telomerase by G-quartet DMA structures

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A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

Hisashi Tamaru, Eric U. Selker · Nature · 2001 · 1K citations

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