Organic Process Research & Development · 2017 · 103 citations · 7 references
PharmacyChemical EngineeringPharmaceuticsDrug Approval ProcessesPharmaceutical ManufacturingPharmaceutical TechnologyChemical Process DesignContinuous Flow ManufacturingDrug ApprovalDrug DevelopmentNew Drug ApplicationsProcess DevelopmentChemical Process DevelopmentContinuous FlowContinuous Flow DesignContinuous Flow ProcessingContinuous Flow SynthesisDrug Product DevelopmentFlow ChemistryFlow-based High-throughput Synthesis
Flow chemistry is playing an increasingly important role in API process development and manufacture in the pharmaceutical and fine chemical industry. The current article reviews routes to approved drugs that employ at least one continuous flow step, disclosed in the patent literature during 2016 and 2017, with a further constraint that the chemistry has not been published in a journal article.
7
14-Step Synthesis of (+)-Ingenol from (+)-3-Carene
Lars Jørgensen, Steven J. McKerrall, Christian A. Kuttruff et al. · Science · 2013 · 344 citations