Synthesis and characterization of a novel aminopolycarboxylate complexant for efficient trivalent f-element differentiation: <i>N</i>-butyl-2-acetamide-diethylenetriamine-<i>N</i>,<i>N</i>′,<i>N</i>′′,<i>N</i>′′-tetraacetic acid

Abstract

The novel metal ion complexant N-butyl-2-acetamide-diethylenetriamine-N,N',N'',N''-tetraacetic acid (DTTA-BuA) uses an amide functionalization to increase the total ligand acidity and attain efficient 4f/5f differentiation in low pH conditions. The amide, when located on the diethylenetriamine platform containing four acetate pendant arms maintains the octadentate coordination sphere for all investigated trivalent f-elements. This compact coordination environment inhibits the protonation of LnL^- complexes, as indicated by lower K₁₁₁ constants relative to the corresponding protonation site of the free ligand. For actinide ions, the enhanced stability of AnL^- lowers the K₁₁₁ for americium and curium beyond the aptitude of potentiometric detection. Density functional theory computations indicate the difference in the back-donation ability of Am³⁺ and Eu³⁺ f-orbitals is mainly responsible for stronger proton affinity of EuL^- compared to AmL^-. The measured stability constants for the formation of AmL^- and CmL^- complexes are consistently higher, relative to ML^- complexes with lanthanides of similar charge density. When compared with the conventional aminopolycarboxylate diethylenetriamine pentaacetic acid (DTPA), the modified DTTA-BuA complexant features higher ligand acidity and the important An³⁺/Ln³⁺ differentiation when deployed on a liquid-liquid distribution platform.