Progesterone inhibited endoplasmic reticulum stress associated apoptosis induced by interleukin‐1β via the GRP78/PERK/CHOP pathway in BeWo cells

Abstract

IL-1β could induce ERS associated cell apoptosis by activating the GRP78/PERK/CHOP signal pathway in BeWo cells and may play an important role in PE occurrence. Progesterone levels were decreased in patients with PE and seemed to have a protective effect by inhibiting ERS associated cell apoptosis.