Xanthones and Quinolones Derivatives Produced by the Deep-Sea-Derived Fungus Penicillium sp. SCSIO Ind16F01

Abstract

Chemical investigation of the fungus <i>Penicillium</i> sp. SCSIO Ind16F01 derived from deep-sea sediment sample afforded a new xanthone, 3,8-dihydroxy-2-methyl-9-oxoxanthene-4-carboxylic acid methyl ester (<b>1</b>) and a new chromone, coniochaetone J (<b>2</b>), together with three known xanthones, 8-hydroxy-6-methyl-9-oxo-9<i>H</i>-xanthene-1-carboxylic acid methyl ester (<b>3</b>), 7,8-dihydroxy-6-methyl-9-oxo-9<i>H</i>-xanthene-1-carboxylic acid methyl ester (<b>4</b>), 1,6,8-trihydroxy-3-(hydroxymethyl)anthraquinone (<b>5</b>), three known chromones, coniochaetone B (<b>6</b>), citrinolactones B (<b>7</b>), epiremisporine B (<b>8</b>), and four reported rare class of <i>N</i>-methyl quinolone lactams: quinolactacins B (<b>9</b>), C1 (<b>10</b>), and C2 (<b>11</b>), and quinolonimide (<b>12</b>). The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. Those isolated compounds were evaluated for their antiviral (EV71 and H3N2) and cytotoxic activities.