Modulation of radiation-induced base excision repair pathway gene expression by melatonin

Abstract

Our results suggested that MLT in mentioned dose may result in modulation of <i>Ogg1</i>, <i>Apex1</i>, and <i>Xrcc1</i> gene expression in peripheral blood cells to reduce X-ray irradiation-induced DNA damage. Therefore, administration of MLT may increase the normal tissue tolerance to radiation through enhancing the cell DNA repair capacity. We believed that MLT could play a radiation toxicity reduction role in patients who have undergone radiation treatment as a part of cancer radiotherapy.