Coenzyme Q10 Regulates Antioxidative Stress and Autophagy in Acute Myocardial Ischemia‐Reperfusion Injury

Abstract

This study reveals that CQ10 preconditioning regulates antioxidant levels and the oxidant balance, enhances autophagy, reduces myocardial apoptosis and death, and improves cardiac function in rats with acute ischemia-reperfusion injury. These results imply that CQ10 protects against acute myocardial ischemia-reperfusion injury via the antioxidative stress and autophagy pathways.