Immune Abnormalities in Patients With Single Ventricle Circulation Precede the Fontan Procedure

Abstract

Single ventricle patients display several immunological abnormalities. Beyond the neonatal age, an immune pattern includes CD3⁺, CD4⁺, CD8⁺ lymphopenia, and CD16⁺ and CD19⁺ lymphocytosis. B-cell lymphocytosis compensates T-cell lymphopenia, producing normal total lymphocyte counts in patients early after Fontan surgery. Low preoperative total lymphocyte counts may be associated with longer postoperative intensive care unit stay in patients with bidirectional Glenn and Fontan procedure and leukopenia with pleural effusions in Fontan patients.