Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

Abstract

A new pyrimidine based Schiff base ligand ( HL ) and its four complexes of type [MLOAc]·<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>n</mml:mi></mml:mrow></mml:math>H 2 O (Cu(II), 1 ; Zn(II), 2 ; Co(II), 3 ; and Ni(II), 4 ) have been synthesized and characterized by elemental analysis, MS, 1 H-NMR, FT-IR, UV-visible, and ESR techniques. The electronic and ESR spectral data suggested that complexes 1 – 4 possess square planar geometry. Antimicrobial activities of HL and complexes 1 – 4 were tested against four bacteria (Staphylococcus aureus , Staphylococcus pneumonia , Salmonella enterica typhi , and Haemophilus influenzae) and two fungal strains (Aspergillus flavus and Aspergillus niger) . These results show that complexes 1 – 4 have good antimicrobial activity compared to HL . The DNA cleavage activity of HL and complexes 1 – 4 was monitored by the agarose gel electrophoresis method. The antioxidant property of the prepared compounds was assessed by using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. DNA binding properties of HL and complexes 1 – 4 have been investigated by electronic absorption technique and viscometric measurements.