Deletion of the <scp>EGF</scp> receptor in vascular smooth muscle cells prevents chronic angiotensin <scp>II</scp>‐induced arterial wall stiffening and media thickening

Abstract

Vascular smooth muscle cell-EGFRs are relevant for pathological AII action in vivo. Our data show in vivo and ex vivo the necessity of VSMC-EGFR for AII-induced structural and functional vascular remodelling, not including endothelial dysfunction. Hereby, VSMC-EGFR gains importance for complete AII-induced renal end-organ damage succeeding vascular remodelling.