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Publication | Open Access

TH17 Cell Frequency in Peripheral Blood Is Elevated in Overweight Children without Chronic Inflammatory Diseases

DOIFull Paper Access

34

Citations

37

References

2017

Year

T. Schindler, Johanna-Josophina Wagner, Sybelle Goedicke‐Fritz, Tobias Rogosch, Verena Coccejus, Verena Laudenbach, Wilfried H. Nikolaizik, Christoph Härtel, Rolf F. Maier, Sebastian Kerzel,
Frontiers in Immunology

Abstract

Childhood obesity is an independent factor that is associated with an elevated frequency of circulating T<sub>H</sub>17 cells and higher expression of RORC- and IL-17A-mRNA after <i>in vitro</i> stimulation with Ionomycin. This might be due to the inflammatory activity of the fat tissue. Studies on T<sub>H</sub>17 immunity should not only be adjusted for acute and chronic inflammatory diseases but also for overweight.

References

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