Anticaries efficacy of a sodium monofluorophosphate dentifrice containing xylitol in a dicalcium phosphate dihydrate base. A 30-month caries clinical study in Costa Rica.

Abstract

Of those subjects who met the initial inclusion/exclusion criteria for this study, 2,539 were available for the 30-month exam. DFS increments over the 30-month period of this clinical study were 1.30 for the test dentifrice containing 10% xylitol, and 1.51 for the positive control dentifrice without xylitol; for DFT, the corresponding increments were 0.69 for the test dentifrice containing 10% xylitol, and 0.81 for that which did not contain xylitol. For both DFS and DFT, the increments associated with the test dentifrice containing 10% xylitol were statistically significantly lower than those associated with the positive dentifrice without xylitol (P < 0.05), with the observed reductions in caries increment exceeding 10% in for both parameters.