Why do so many clinical trials of therapies for Alzheimer's disease fail?

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Bradley T. Hyman, Creighton H. Phelps, Thomas G. Beach et al. · Alzheimer s & Dementia · 2012 · 3.1K citations · Full text

Alzheimer's Disease Neuroimaging Initiative (ADNI)

Ronald C. Petersen, Paul Aisen, Laurel Beckett et al. · Neurology · 2009 · 2.4K citations · Full text

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

Jeffrey L. Cummings, Travis Morstorf, Kate Zhong · Alzheimer s Research & Therapy · 2014 · 1.7K citations · Full text

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

Rachelle S. Doody, Rema Raman, Martin R. Farlow et al. · New England Journal of Medicine · 2013 · 1.2K citations

The Uniform Data Set (UDS): Clinical and Cognitive Variables and Descriptive Data From Alzheimer Disease Centers

John C. Morris, Sandra Weıntraub, Helena C. Chui et al. · Alzheimer Disease & Associated Disorders · 2006 · 950 citations

Neuropsychology, Aging, Uniform Data Set +20