Albumin/sulfonamide stabilized iron porphyrin metal organic framework nanocomposites: targeting tumor hypoxia by carbonic anhydrase IX inhibition and <i>T</i>₁–<i>T</i>₂ dual mode MRI guided photodynamic/photothermal therapy

Abstract

) and allow synergetic photodynamic/photothermal therapy of tumors. In vitro reactive oxygen species (ROS) detection and photothermal temperature change results revealed that these BSA/SAs-NMOF nanoplatforms could exhibit a great PDT effect in tumor cells, even under hypoxic conditions, and a remarkable PTT effect with a photothermal conversion efficiency of 40.53%. What's more, there was a greater fatality rate of 4T1 cancer cells in the single wavelength induced PDT & PTT group (95%) than in the PDT or PTT monotherapy groups (nearly 80%), and the growth of a solid tumor was more effectively inhibited by PDT & PTT than by single PTT or PDT. This work provides a novel nanoplatform for targeting tumor hypoxia and achieved highly efficient treatment of tumors based on PDT and PTT.