Carcinogenic Etheno DNA Adducts in Alcoholic Liver Disease: Correlation with Cytochrome P‐4502E1 and Fibrosis

Abstract

These data suggest an important role of CYP2E1 in the generation of εdA, in the fibrotic progression of ALD, and thus in alcohol-mediated hepatocarcinogenesis. CYP2E1 may be a target in the treatment of ALD and a potential prognostic marker for disease progression.